A new study describes themechanistic relationship between thecytokine interleukin-1β(IL-1β) and obesity. WhenIL-1βlevels increase in obesity, theactivation ofIL-1receptor signaling leads to a large number of colon cancers. Kinds of ways. This study shows that obesity is related tothe systemic increase ofIL-1β,the activation ofWntand the proliferation of mouse colon cells.
Joel Mason na Tufts University a Massachusetts da Tufts University School of Medicine da abokan aiki a jami’ar Tufts sun hada labarin ”Interleukin- 1 Siginiyar Masu shiga tsakani na Kiba-inganta Karuwar Cytokines mai kumburi, Wnt Activation, da Small . "
Masu binciken sun shirya don tantance rawar da IL-1β ke takawa wajen daidaita al'amuran da ke haifar da haifar da kiba mai kawo ciwan kai tsaye. Sun kwatanta rawar IL-1β a cikin beraye masu abinci mai ƙoshin mai (mai kiba) ko mai ƙoshin mai (mai rauni). Ofaya daga cikin canje-canjen da aka same su a cikin ƙananan bera masu ciwon murji na ciki 30-80% mafi girma na IL-l [beta], Wnt cascade ya haɓaka haɓakar sigina da ƙaruwa sosai a cikin yankin mallaka.
"Wannan binciken ya nuna kusancin alaƙar da ke tsakanin kiba da amsawar mai kumburi, kuma ya nuna irin rawar da IL-1β ke takawa, yana bayyana kiba a matsayin ɗayan yawancin cututtukan da ke haifar da kumburi," Ma'aikatar Immunology, Jami'ar Washington, Cibiyar Kula da unitywayar Cutar da Cututtuka da Cututtuka. Michael Gale Jr., babban edita na Jaridar Interferon & Cytokine Research, ya ce.
