Nuwamba 2022: Haɗin doxorubicin, vincristine, etoposide, prednisone, da cyclophosphamide tare da brentuximab vedotin (Adcetris, Seagen, Inc.) an amince da su ta Cibiyar Abinci da Magunguna don amfani da yara da matasa waɗanda ke da babban haɗari na gargajiya Hodgkin lymphoma waɗanda ba su da haɗari. samu magani a baya (cHL). Wannan shine farkon amincewar likitan yara na brentuximab vedotin.
An yi amfani da gwajin bazuwar, buɗaɗɗen lakabin, gwaji mai sarrafa gaske don tantance tasiri. Mataki na IIB tare da rashin lafiya mai yawa a Ann Arbor, Stage IIIB, Stage IVA, da Stage IVB duk an rarraba su azaman babban haɗari. Brentuximab vedotin da doxorubicin (A), vincristine (V), etoposide (E), prednisone (P), da cyclophosphamide (C) [brentuximab vedotin + AVEPC] an bai wa marasa lafiya 300, yayin da A+bleomycin (B)+V+ An ba E+P+C [ABVE-PC] ga marasa lafiya 300. Kowane majinyatan hannun jiyya na iya yin hawan keke 5 na masu zuwa:
Prednisone 20 mg/m2 BID (kwanaki 1-7), cyclophosphamide 600 mg/m2 (kwanaki 1 da 2), doxorubicin 25 mg/m2 (kwanaki 1 da 2), vincristine 1.4 mg/m2 (kwanaki 1 da 8), etoposide 125 mg/m2 (kwanaki 1-3), da brentuximab vedotin 1.8 mg/kg sama da mintuna 30 (rana (kwanaki 1 da 2).
Rayuwa ba tare da abin da ya faru ba (EFS), wanda shine lokacin daga bazuwar zuwa farkon ci gaban cuta ko sake dawowa, rashin lafiya na biyu, ko mutuwa daga kowane dalili, yayi aiki azaman ma'aunin sakamako na farko. A cikin kowane hannu ba a sami matsakaicin EFS ba. Tare da daidaitaccen haɗarin haɗari na 0.41 (95% CI: 0.25, 0.67; p = 0.0002), akwai abubuwan 52 (17%) a cikin hannun ABVE-PC da abubuwan 23 (8%) a cikin brentuximab vedotin + AVEPC hannu.
In paediatric patients receiving brentuximab vedotin in combination with AVEPC, neutropenia, anaemia, thrombocytopenia, febrile neutropenia, stomatitis, and infection were the most frequent Grade 3 adverse events (5%).
Ga yara masu shekaru 2 da haihuwa, shawarar brentuximab vedotin da aka ba da shawarar shine 1.8 mg/kg har zuwa 180 MG tare da AVEPC kowane mako 3 don matsakaicin allurai 5.
Duba cikakken bayanin rubutawa don Adcetris.
