Colorectal ciwon daji
The researchers found that adding SIRT to chemotherapy can improve yawan tsira na maganin ciwon daji
New research shows that for patients with colorectal cancer who have only liver metastases or mainly liver metastases, adding selective in vivo radiotherapy based on standard first-line mFOLFOX6 chemotherapy can significantly increase the median overall survival time of patients with primary tumors on the right.
Farfesa Guy van Hazel na Jami'ar Yammacin Ostiraliya ya ce: "Bincikenmu yana buƙatar ƙarin tabbaci, don haka za mu iya yin la'akari da zaɓuɓɓukan amfani da wuri don marasa lafiya masu ciwon hanta na farko da ke da ciwon daji na hanji (mCRC) waɗanda ke da ciwon hanta kawai ko kuma yawancin hanta. Jima'i a cikin vivo radiotherapy (SIRT). "Ya kara da cewa:" Wadannan binciken labarai ne mai kyau ga marasa lafiya da ciwace-ciwacen dama. Suna da tsinkaye mafi muni da ƙarancin zaɓuɓɓukan magani fiye da marasa lafiya da ciwace-ciwacen hagu. "
Wurin da ke da ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta muhimmiyar mahimmanci ce mai mahimmanci da kuma tsinkayar amsawar jiyya. Alal misali, binciken da aka yi a shekara ta 2016 ya nuna cewa marasa lafiya da ciwon daji na farko a gefen dama suna da mummunan amsa da tsinkaye fiye da marasa lafiya da ciwon daji na farko a gefen hagu.
Gwajin inganci da amincin SIRT
SIRT wani nau'i ne na in vivo radiotherapy don Y-90 resin microspheres, wanda ake gudanarwa ta hanyar catheter na intrahepatic. Beta radiation microspheres zai fi dacewa isa ga tsarin microvascular kewaye da ƙari, wanda zai iya rage tasirin tsarin.
An yi amfani da SIRFLOX, FOXFIRE da FOXFIRE nazarin duniya don kimanta inganci da amincin chemotherapy na tushen oxaliplatin na farko tare da SIRT don mCRC wanda ba a iya jurewa ba. A cikin binciken da aka haɗa, marasa lafiya 554 sun karɓi chemotherapy tare da SIRT, kuma marasa lafiya 549 sun karɓi chemotherapy kawai. Matsakaicin jimlar lokacin rayuwa shine watanni 22.6 da watanni 23.3, bi da bi. A cikin binciken da aka yi bayan mutuwar mutum, an gano wurin da ciwon farko ya kasance a kan takardar rahoton ƙungiyar. Ciwon daji na dama an bayyana shi a matsayin kowane ƙwayar cuta ta farko a kusa da ƙarshen splenic flexure, kuma ƙwayar hagu an bayyana shi a matsayin duk wani ƙari a splenic flexure, mafi nisa daga hanji ko Ciwon Farko a cikin dubura.
SIRT da chemotherapy na iya tsawaita lokacin rayuwa
Sakamakon ya nuna cewa matsakaicin lokacin rayuwa gaba ɗaya na marasa lafiya tare da ciwace-ciwacen ƙwayar cuta na mCRC shine watanni 24.6 a cikin chemotherapy tare da ƙungiyar SIRT, da watanni 26.6 a cikin ƙungiyar chemotherapy kadai. Koyaya, matsakaicin lokacin rayuwa gaba ɗaya na majinin ciwon daji na mCRC shine watanni 22 a cikin chemotherapy da ƙungiyar SIRT, da watanni 17.1 a cikin ƙungiyar chemotherapy kaɗai. Daidaitaccen gwajin ƙididdiga na tasirin jiyya akan lokacin rayuwa gabaɗaya ta wurin kuma ya tabbatar da cewa gefen ƙari ya fi mahimmanci.
One hypothesis is that right-sided tumors not only have a poorer prognosis, they are more resistant to chemotherapy, and may be more sensitive to radiation therapy with a completely different mechanism of action.
Rashin sakamako mai kyau a cikin binciken gabaɗaya na iya kasancewa saboda haɗar marasa lafiya tare da ƙwayar ƙwayar cuta ta extrahepatic metastases. Kodayake SIRT na iya sarrafa cututtukan hanta, ba zai iya sarrafa cututtukan hanta ba.
