Mingyang Song de la Harvard Medical School et du Massachusetts General Hospital ont rapporté qu'après le diagnostic de cancer colorectal non métastatique, l'ingestion de plus de fibres réduirait la mortalité spécifique et la mortalité globale du cancer colorectal. L'augmentation de l'apport en fibres après le diagnostic peut bénéficier aux patients atteints de cancer colorectal. (JAMA Oncol. Version en ligne le 2 novembre 2017).
Although it has been shown that high dietary fiber intake reduces the risk of colorectal cancer, it is not clear whether high fiber intake will benefit colorectal survivants du cancer.
Pour évaluer la relation entre l'apport en fibres et la mortalité, l'étude a inclus 1575 patients atteints d'un cancer colorectal de stade I à III de deux cohortes prospectives; après ajustement pour d'autres prédicteurs potentiels de survie au cancer, la spécificité du cancer colorectal a été déterminée Mortalité et mortalité totale.
Entre 6 mois et 4 ans après le diagnostic de cancer colorectal, les chercheurs ont utilisé un questionnaire validé sur la fréquence des repas pour évaluer l'apport total en fibres, la quantité de fibres provenant de différentes sources et la quantité de blé entier.
Among the 1575 participants, 963 (61.1%) were women; the average age was 68.6 years. With a median follow-up of 8 years, 773 patients died, of which 174 died from colorectal cancer. A high total fiber intake after diagnosis is associated with a lower mortality rate. For every 5g increase in daily intake, the multivariable HR for colorectal cancer specific mortality and all-cause mortality were 0.78 (95% CI 0.65 ~ 0.93; P = 0.006) and 0.86 (95% CI 0.79 ~ 0.93) P <0 .001). According to fiber sources, cereal fiber can reduce colorectal cancer-specific mortality (for every 5 g / d increase in intake, HR = 0.67, 95% CI 0.50 ~ 0.90; P = 0.007) and all-cause mortality (HR = 0.78, 95% CI 0.68 ~ 0.90; P <0.001); vegetable fiber can reduce all-cause mortality (HR = 0.83, 95% CI 0.72 ~ 0.96; P = 0.009), but it does not reduce colorectal cancer-specific mortality (HR = 0.82, 95% CI 0.60 ~ 1.13; P = 0.22); No correlation was found between fruit fiber and mortality. Ingestion of whole wheat food can reduce the specific mortality of colorectal cancer (for every 20 g / d increase in intake, HR = 0.72, 95% CI 0.59 ~ 0.88; P = 0.002), but the correlation It will weaken after entry (HR = 0.77, 95% CI 0.62 ~ 0.96; P = 0.02).
