دستیابی به موفقیت در داروهای تومور مغزی در دوران کودکی

پیشرفت بزرگی در توسعه داروهای تومور مغزی در دوران کودکی وجود دارد. تومورهای مغزی کودکان یک بیماری بدخیم شایع در کودکان است. تحقیقات اخیر نشان داده است که یک داروی کوکتل جدید می تواند تومورهای مغزی رایج دوران کودکی را درمان کند.

Cancer Cell” magazine recently announced that in the UK, about 400 children develop brain تومور each year, of which the prevalence of boys is slightly higher than that of girls.

Are we able to take advantage of the results of tumor gene testing and tailor-made treatments, a strategy often referred to as personalized medicine? This treatment strategy can produce very good results for patients with brain tumors.

Neural myeloblastoma (medulloblastoma) is one of the most common تومورهای بدخیم of the cerebellum. This تومور مغزی grows rapidly and most often occurs in children around the age of 5. گزینه های درمان include surgery, radiation, and chemotherapy. Although great progress has been made in treatment methods and techniques, the success rate of treating myeloblastoma still lags far behind other children’s malignancies. In particular, myeloblastoma is a highly aggressive malignancy. Only 40% of patients with مدولوبلاستوما survive, compared with other tumors of a less severe type-with a survival rate of more than 80%.

Researchers in the United States have discovered a new combination therapy for the treatment of highly aggressive نوروبلاستوما. In laboratory tests, the drug killed سرطان cells without any toxicity to normal cells, and researchers hope to conduct clinical trials of the drug. Robert Wechsler-Reya, an adjunct professor at the Sanford Burnham Prebys Medical Institute, said: “Our goal is to confirm that the drug has low toxicity properties. Because doctors and patients in this case urgently require new clinical treatment options, we will soon apply the drug from the laboratory to clinical treatment.

با ترکیب با داروهای دیگر ، ترکیبات جدیدی که تومورها را مهار می کنند ، in vitro و in vivo غربال می شوند.

کارآزمایی های بالینی for neuroblastoma are often very challenging because of the limited number of patients. In addition, coupled with the variability of the disease, most treatments are only effective for one subtype of patient. Understanding which patients will respond to this treatment is one of the main goals of the trial.

"اگر ما بتوانیم درمان های سفارشی را بر اساس ژن های تومور توسعه دهیم - استراتژی ای که معمولاً به عنوان درمان فردی شناخته می شود - این می تواند انجیل عظیمی را برای بیماران دارای تومورهای خاص به ارمغان آورد."

نوروبلاستوما چهار نوع متمایز دارد و بیماران با گروه سوم تومورها بدترین پیش آگهی را دارند - فقط 40٪ بیماران در طولانی مدت زنده می مانند. در مقابل ، بقای طولانی مدت سایر نوروبلاستوما نسبتاً خوش بینانه است و حدود 80٪ بیماران می توانند به مدت طولانی زنده بمانند.

بيشتر گروه سوم بيماران مبتلا به نوروبلاستوما بيان انكوژن MYC را دارند كه علت تقسيم بندي سلولي غيرقابل كنترل و تشكيل تومور است.

There was a study on mice with a third type of neural tube cell tumors that showed histone deacetylase inhibitors (HDACIs) and phosphatidylinositol 3-kinase inhibitors (PI3KIs) might stop mice and people from making neurotubular glioblastomas without doing too much damage to normal cells.

We found several histone deacetylase inhibitors that can kill MYC oncogene-activated neural tube cell tumors without harming normal cell agents (HDACIs),” said Pei Yanxin, an assistant professor at the National Children’s مرکز پزشکی در واشنگتن، دی سی

The most effective of these compounds is panobinostat, which has entered clinical trials in other انواع سرطان, but has not yet been tested on neuroblastoma.” Dr. Kun-Wei, a postdoctoral researcher at Stanford University, added: “Several other studies have revealed that the mechanism of action of panobinostat is to promote the activation of the FOXO1 gene that can interfere with the oncogenes of MYC.

Phosphatidylinositol 3-kinase inhibitors (PI3KIs) are also thought to have the effect of activating the FOXO1 gene. We hypothesized that panobinostat and phosphatidylinositol 3-kinase inhibitors (PI3KIs) could work together to block سرطان سلول بقا

“It is true that the combined treatment of these two drugs can significantly increase the survival of patients with tumors carrying the MYC gene compared to using a single drug alone.”