A study reported by Yasuhito Tanaka of the Nagoya City University Medical Department in Japan showed that the single nucleotide polymorphism (SNP) in the TLL1 gene is related to the occurrence and development of hepatocellular carcinoma after radical cure of hepatitis C virus infection. (Gastroenterology. 2017, 152: 1383-1394.) The researchers established different models by combining TLL1 gene mutation with other significant risk factors to predict the risk of liver cancer in patients with different degrees of liver fibrosis. TLL1 gene variants can be used to predict the risk of lewerkanker in patients who have achieved a sustained virological response (SVR) in clinical practice. The study included Japanese patients who still suffered from liver cancer after interferon eradication of hepatitis C virus, and used genome-wide association analysis to identify which genes were mutated. The results showed that the TNP1 gene SNP rs17047200 on chromosome 4 is closely related to the occurrence of liver cancer after eradication of hepatitis C virus. There is no obvious linkage disequilibrium between other SNPs and rs17047200, and no more promising SNPs have been found in the exons and promoter regions of TLL1. Tanaka commented: “The mutant genes of liver cancer caused by hepatitis C virus include MICA and DEPDC5, which is very different from our test results.” In a multivariate analysis, the AT / TT base pairing of rs17047200 may lead to a 78% increased risk of liver cancer (P = 0.008). In the group of patients with mild fibrosis, older age is an independent risk factor for liver cancer; in the group of severe fibrosis, postoperative alpha-fetoprotein level and low albumin level are also risk factors. In two groups of liver fibrosis rat models, the mRNA level of TLL1 has increased, but only one group of models of TLL1 mRNA level is consistent with the progress of liver fibrosis. The level of TLL1 mRNA in patients with chronic hepatitis C also increases as liver fibrosis worsens.
Tananka het daarop gewys: “Hierdie data toon aanvanklik die verwantskap tussen TLL1 / Tll1-uitdrukking en hepatiese stellaatselaktivering of hepatiese fibrose-vordering in diere of in vitro en in mense (die model is nie-alkoholiese steatohepatitis-verwante lewerkanker). Dit kan dalk 'n nuwe meganisme van lewerfibrose of kanker opklaar. Nadat die pasiënt radikale behandeling vir hepatitis C-virus ontvang het en SVR verkry het, kan TLL1 SNP-verwante eksperimente gebruik word om mense met die risiko van lewerkanker te identifiseer. As TLL1 SNP vergelyk word met Die kombinasie van ouderdom, graad van fibrose, hoë alfa-fetoproteïenvlak en ander beduidende risikofaktore kan help om die risiko van lewerkanker na SVR klinies te voorspel. Geen interferon orale behandelingsplan gekombineer met direkwerkende antivirale geneesmiddelterapie nie, word die standaard anti-hepatitis C-virusterapie in ontwikkelde lande. Verdere navorsing is egter steeds nodig om te bepaal of TLL1-mutasies verband hou met die voorkoms van lewerkanker na behandeling met interferonvrye SVR.
