The latest research found that some statins can improve the efficacy of chemotherapy drugs used to treat blood cancer in mouse models. Statins are drugs that treat patients with reduced fat in the blood. They are commonly used to lower triglyceride and cholesterol levels and reduce fat associated with heart attacks and strokes. In this new experiment, the researchers found that they may also be used to treat certain blood cancers.
Vorige navorsing het getoon dat statiene apoptose (natuurlike seldood) in sekere soorte kanker bevorder, en hierdie bevinding dui daarop dat dit nuttig kan wees in die behandeling van hierdie kankers. In hierdie studie het die navorsers bevind dat simvastatien die doeltreffendheid van Venetoclax teen chroniese limfositiese leukemie in 'n muismodel verbeter het. Dit help om limfoom te verminder deur die apoptose-sein in kankerselle te verhoog, wat lei tot verhoogde oorlewingstyd. Hulle het ook daarop gewys dat hierdie bevinding meer effektief is as enige middel wat alleen gegee word.
The researchers were encouraged by the results of this study and began three clinical trials involving the testing of Venetoclax for the treatment of chronic lymphocytic leukemia, looking for data on patients who had received statins. They found that these patients responded better to cancer by 2.7 times than those who did not take statins.
Navorsers sê dat as statiene dieselfde effek by mense het, miljoene mense regoor die wêreld dit dikwels gebruik om cholesterolvlakke te verlaag. Benewens die vermindering van vet in die bloed, is daar ook getoon dat hulle geen newe-effekte het nie. Volgens die navorsers moet kliniese toetse uitgevoer word om vas te stel of statiene die prognose van pasiënte met leukemie en ander bloedkanker kan verbeter.
