Mingyang Song van Harvard Medical School en Massachusetts General Hospital berig dat na diagnose van nie-metastatiese kolorektale kanker, die inname van meer vesel die spesifieke mortaliteit en algehele mortaliteit van kolorektale kanker sal verminder. Die verhoging van veselinname na diagnose kan pasiënte met kolorektale kanker bevoordeel. (JAMA Oncol. Aanlyn weergawe op 2 November 2017).
Although it has been shown that high dietary fiber intake reduces the risk of colorectal cancer, it is not clear whether high fiber intake will benefit colorectal kankeroorwinnaars.
Om die verband tussen veselinname en mortaliteit te bepaal, het die studie 1575 pasiënte met stadium I tot III kolorektale kanker uit twee voornemende groepe ingesluit; na aanpassing vir ander potensiële kankeroorlewingsvoorspellers, is die spesifiekheid van die kolorektale kanker bepaal Mortaliteit en totale sterfte.
Tussen 6 maande en 4 jaar na die diagnose van kolorektale kanker, het die navorsers 'n gevalideerde vraelys oor die frekwensie van eet gebruik om die totale veselinname, die hoeveelheid vesel uit verskillende bronne en die hoeveelheid volgraan te bepaal.
Among the 1575 participants, 963 (61.1%) were women; the average age was 68.6 years. With a median follow-up of 8 years, 773 patients died, of which 174 died from colorectal cancer. A high total fiber intake after diagnosis is associated with a lower mortality rate. For every 5g increase in daily intake, the multivariable HR for colorectal cancer specific mortality and all-cause mortality were 0.78 (95% CI 0.65 ~ 0.93; P = 0.006) and 0.86 (95% CI 0.79 ~ 0.93) P <0 .001). According to fiber sources, cereal fiber can reduce kolorektale cancer-specific mortality (for every 5 g / d increase in intake, HR = 0.67, 95% CI 0.50 ~ 0.90; P = 0.007) and all-cause mortality (HR = 0.78, 95% CI 0.68 ~ 0.90; P <0.001); vegetable fiber can reduce all-cause mortality (HR = 0.83, 95% CI 0.72 ~ 0.96; P = 0.009), but it does not reduce colorectal cancer-specific mortality (HR = 0.82, 95% CI 0.60 ~ 1.13; P = 0.22); No correlation was found between fruit fiber and mortality. Ingestion of whole wheat food can reduce the specific mortality of colorectal cancer (for every 20 g / d increase in intake, HR = 0.72, 95% CI 0.59 ~ 0.88; P = 0.002), but the correlation It will weaken after entry (HR = 0.77, 95% CI 0.62 ~ 0.96; P = 0.02).
