CAR T-Cell therapy in China

The groundbreaking cancer treatment CAR T-cell therapy has attracted a lot of attention lately due to its astounding efficacy in curing some tumors. China has emerged as a global leader in the sector, achieving substantial advancements in CAR T-cell research and implementation, despite the fact that the therapy was initially created in the United States. CAR-T therapy is a novel form of cancer treatment using the immune system to eradicate cancer cells. Where other therapies have failed, it has occasionally been able to heal patients. This article will highlight all that you need to know about this procedure and current status of CAR T-Cell therapy in China. Read on to find out more!

CAR T Cell therapy in China


The goal of CAR T-cell therapy is to specifically target cancer cells by reprogramming a patient’s T-cells, which are part of their immune system. In treating hematological malignancies, such as leukemia and lymphoma, where conventional medicines have frequently failed, this individualized therapeutic method has shown encouraging outcomes.
The development of CAR T-cell treatment in China is the result of a number of reasons. The nation’s big patient population, which offers a sizable pool of people for clinical trials and treatment, comes first. Due of the large number of patients, Chinese researchers have been able to collect extensive data and improve their methodologies.
The regulatory climate in China has also facilitated the quick development and widespread use of CAR T-cell treatments. Fast-track approval procedures have been established in the nation for novel medical technology, enabling quick review and uptake of new treatments. For Chinese patients, this has improved the accessibility and availability of CAR T-cell therapies.
Numerous clinical trials have been done to assess the safety and efficacy of these treatments, with Chinese biotech companies and research institutions at the forefront of CAR T-cell therapy research. Notably, the Chinese biotechnology company Juno Therapeutics, working with Chinese medical facilities, has had outstanding success treating patients with B-cell acute lymphoblastic leukemia who have relapsed or are resistant to treatment.
China’s innovations in CAR T-cell treatment have had an impact on the world as well as its own people. Chinese scholars have actively shared their research and worked with international colleagues, advancing the field as a whole. Furthermore, China’s industrial prowess has allowed for the mass production of CAR T-cell therapies, increasing its accessibility and affordability for patients all around the world.
To sum up, China has become a significant actor in the creation and use of CAR T-cell therapy. The nation has advanced in this ground-breaking cancer treatment thanks to its sizable patient population, a supportive regulatory framework, and cooperative research activities. China’s position as a global leader in CAR T-cell treatment is set to grow with ongoing research and innovation, giving cancer patients there and around the world hope.

What is CAR-T Cell Therapy?

This type of therapy involves modifying the patient’s T cells, an immune cell type, in the lab so they will bind to and kill cancer cells. A tube transports blood from a vein in the patient’s arm to an apheresis device (not shown), which extracts white blood cells, including T cells, and returns the remaining blood to the patient. 

The T cells are then genetically modified in the lab to contain the gene for a unique receptor known as a chimeric antigen receptor (CAR). The CAR T cells are multiplied in a lab before being infused into the patient in large numbers. The antigen on the cancer cells can be recognized by CAR T cells, which then kill the cancer cells.

CAR-T-Cell- therapy in China

What is the procedure for CAR-T Cell therapy?

The CAR-T therapy procedure, which takes a few weeks, involves multiple steps:

T cells are extracted from your blood using a tube that is placed into an arm vein. This takes a couple of hours.

T cells are transported to a facility where they undergo genetic modification to become CAR-T cells. Two to three weeks pass throughout this.

CAR-T cells are reintroduced into your bloodstream through a drip. This requires several hours.

CAR-T cells target and eliminate cancer cells throughout the body. After receiving CAR-T therapy, you will be closely watched.

What are the side effects of CAR-T Cell therapy?

Cytokine release syndrome, or CRS, is the typical CAR T-cell side effect. Another name for it is “cytokine storm.” It is experienced by roughly 70–90% of patients, but it only lasts for five to seven days. The majority of people compare it to having a bad flu infection, complete with a high fever, exhaustion, and bodily aches. 

The second or third day following the infusion is typically when it begins. It occurs due to the body’s immune system reacting to the T cells’ proliferation and attack on the malignancy.

CRES, which stands for CAR T-cell-related encephalopathy syndrome, is the other adverse impact. Around day five following the infusion, it usually begins. Patients may have confusion and disorientation, and occasionally they may be unable to talk for several days. 

Although CRES is reversible and normally lasts between two and four days, it can be stressful for patients and their families. All neurological functions gradually return to normal in patients.

What type of cancer cells can be treated with CAR-T Cell Therapy? 

Only patients with adult B-cell non-lymphoma Hodgkin’s or pediatric acute lymphoblastic leukemia who have already tried two unsuccessful conventional therapies can currently use CAR T-cell therapy products that have received FDA approval. However, CAR T-cell therapy is now being tested in clinical studies as a first or second-line treatment for adult lymphoma and pediatric acute lymphoblastic leukemia.

What are the advantages of CAR-T Cell Therapy?

The main benefit is that CAR T-cell therapy only requires a single infusion and often only requires two weeks of inpatient care. Patients with non-Hodgkin lymphoma and pediatric leukemia who have just been diagnosed, on the other hand, typically need chemotherapy for at least six months or more.

The advantages of CAR T-cell therapy, which is actually a living medication, can persist for many years. If and when a relapse occurs, the cells will still be able to identify and target cancer cells because they can survive in the body for an extended period of time. 

Although the information is still developing, 42% of adult lymphoma patients who underwent CD19 CAR T-cell treatment were still in remission after 15 months. And after six months, two-thirds of patients with pediatric acute lymphoblastic leukemia were still in remission. Unfortunately, these patients had exceedingly aggressive tumors that weren’t successfully treated using traditional standards of care.

What type of patients would be good recipients of the CAR-T Cell Therapy?

The optimum candidate for CAR T-cell therapy at this time is a juvenile with acute lymphoblastic leukemia or an adult with severe B-cell lymphoma who has already had two lines of ineffective therapy. 

Before the end of 2017, there was no accepted standard of care for patients who had already gone through two lines of therapy without experiencing remission. The only FDA-approved treatment that has so far proven to be significantly beneficial for these patients is CAR T-cell therapy.

What is the scope of CAR-T Cell Therapy in China?

The use of chimeric antigen receptor (CAR) T-cell treatments in the treatment of hematological malignancies has been incredibly effective. The application of CAR T-cell treatments has grown in China over the past nine years. 

The first CAR T cell clinical studies started in 2013, and by 2017 there were more CAR T cell clinical trials than ever before. Soon after, China announced that it would provide a total of US$237 billion in funding for cell therapy businesses in 2021, which represented a huge increase in the number of clinical trials and fundamental research projects involving CAR T cells.

Strong government support, money inflow, high patient demand, a distinctive healthcare system, and the efforts of Chinese doctors and scientists all contributed to this significant surge in activity in China.

To Conclude

This represents a significant advancement in the management of leukemia and B-cell lymphoma. Additionally, it gives hope to those whose lives had previously been predicted to last only six months. Now that we have identified mechanisms of resistance and created more techniques to combat them, the future appears to be much more promising.

For more details on CAR-T Cell Therapy in China, head over to our website. Get in touch with our highly experienced healthcare providers here at Cancerfax for a free consultation to work out a suitable care plan for your healthcare needs!

CAR T Cell therapy hospital in China

Image: One of the hospital in China that runs clinical trials in Car T-cell therapy


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